Neuro-Audiology (NA)
O'neil Guthrie, PhD
Associate Professor
Northern Arizona University
Flagstaff, Arizona
Financial Disclosures: I do not have any relevant financial relationships with anything to disclose.
Non-Financial Disclosures: I do not have any relevant non-financial relationships with anything to disclose.
We investigated whether an ester of quinic acid could be used to restore neural function after noise exposure. Twenty-six hooded male Long-Evans rats (263 ± 63 g) served as subjects for this experiment. All animals exhibited baseline auditory function that approximated normative values for rats of the same strain. The results revealed that ABR wave I amplitudes at suprathreshold levels was rescued from noise induced neuropathy following treatment with esters of quinic acid. This finding suggests that future biomedical interventions may complement more traditional interventions to provide a more comprehensive management of hearing loss.
Summary:
Rationale: Noise exposure in known to induce neuropathy as revealed by the latency-intensity function of ABR wave-I. In the current study we investigated whether an ester of quinic acid could be used to restore neural function after noise exposure. Design: This research employed a 4 x 4 split-plot factorial design, with 4 levels of the within subject factor (time: baseline, 1 day, 1 week & 1 month post-noise exposure) and 4 levels of the between-subject factor (experimental groups: control, noise exposed, therapy and noise exposed+therapy). Twenty-six hooded male Long-Evans rats (263 ± 63 g) served as subjects for this experiment. All animals exhibited baseline auditory function that approximated normative values for rats of the same strain. Results: The results revealed that ABR wave I amplitudes at suprathreshold levels was rescued from noise induced neuropathy following treatment with esters of quinic acid. Conclusion: This finding suggests that future biomedical interventions may complement more traditional interventions (e.g., hearing aids and cochlear implants) to provide a more comprehensive management of hearing loss.